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Article Dans Une Revue ACS Macro Letters Année : 2021

Protein Nanocapsules Produced by Nanoprecipitation of Designed Suckerin-Silk Fusion Proteins

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Herein, we report on the precise design of a modular fusion protein amenable to the construction of nanocapsules by nanoprecipitation. The central squid suckerin-derived peptide block provides structural stability, whereas both termini from silk fibroins make the modular protein highly soluble at physiological pH, a critical requirement for the nanoprecipitation process. With this molecular design, nanocapsules consisting of suckerin-silk fusion protein shells and hexadecane or miglyol cores with sizes in the range 190-250 nm are straightforwardly built.

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hal-03264411 , version 1 (18-06-2021)

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Ricardo Ramos, Kenrick Koh, Bartosz Gabryelczyk, Luxiao Chai, Kanagavel Deepankumar, et al.. Protein Nanocapsules Produced by Nanoprecipitation of Designed Suckerin-Silk Fusion Proteins. ACS Macro Letters, 2021, 10 (5), pp.628-634. ⟨10.1021/acsmacrolett.1c00171⟩. ⟨hal-03264411⟩
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